Autoimmune Hepatitis
DOI:
https://doi.org/10.58427/apghn.1.1.2022.17-27Keywords:
autoimmune hepatitis, children, genetic disorder, diagnosisAbstract
Autoimmune hepatitis (AIH) is a condition caused by self-perpetuating immune response towards hepatocytes in liver. In children, AIH may progressed more rapidly compared to adults. Thus, early diagnosis and prompt treatment are the key for successful management of AIH. Five main characteristics of AIH include female predominance, increased IgG or hypergammaglobulinemia, circulatory autoantibody seropositivity, and hepatitis interface from the histological finding. Liver biopsy is needed to evaluate the degree of damage and to confirm the diagnosis. The standard regiment for AIH include prednisone (or prednisolone) and azathioprine. Other alternative treatments available for non-responder, such as mycophenolate mofetil, tacrolimus, cyclosporine, budesonide, rituximab, and infliximab. AIH treatment is recommended to be taken minimally for 2-3 years before attempting treatment termination.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Fatima Safira Alatas, Gryselda Hanafi, Lestari Kanti Wilujeng, Nielda Kezia Sumbung
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.